Macquarie Group chief executive Allan Moss will step down from the top job in May.
Macquarie Capital head Nicholas Moore will replace Moss, who has been in the role for almost 15 years, on May 24.
"Allan has been an extraordinarily successful chief executive," Macquarie Group chairman David Clarke said.
"Under Allan's leadership, Macquarie has transformed from an almost entirely domestic business to one earning a majority of its income outside Australia."
Moore said it had been a great privilege to work closely with Moss over the past 22 years.
"Allan's achievements are enduring and we will all benefit from his legacy," he said.
"He leaves Macquarie well positioned for growth."
Under Moss's tenure, staff numbers grew ninefold, while profits increased 30-fold.
Clarke also said the group expected to post a profit of at least $1.8 billion for the year ending March 2008.
"Nicholas takes over leadership of the group as we reaffirm our guidance that this will be another record year," he said.
Michael Carapiet will replace Moore as head of Macquarie Capital. Carapiet is currently global joint head of Macquarie Capital Advisers, a role he has had since 2001.